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(S)-(+)-Epichlorohydrin CAS 67843-74-7

Chemical name: (S)-(+)-Epichlorohydrin

Synonymous names:(S)-Epichlorhydrin;2(S)-Epichlorohydrin;

Oxirane,2-(chloroMethyl)-, (2S)-;(S)-(+)-Epichlorohyd

CAS No:67843-74-7

Molecular formula:C3H5ClO

Molecular weight:92.52

EINECS No:614-150-5

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Structural formula  

Product Description

Items

Specifications

Appearance

Transparent Liquid

Assay,%

99.0MIN

Melting point

−57 °C (lit.)

Boiling point

92-93 °C 360 mm Hg (lit.)

Specific rotation

34 º (589nm, c=1, MeOH)

Density

1.183 g/mL at 25 °C (lit.)

Vapor density

3.2 (vs air)

 

Properties and Usage:

Medicinal chemistry

(S)-(+)-Epichlorohydrin plays an important role in drug synthesis, especially in the synthesis of chiral drug molecules. Its epoxy group is highly reactive and is particularly suitable for drug synthesis related to metabolism in organisms. It acts as an inhibitor of fatty acid oxidation and has potential as a metabolic modulator for the treatment of certain metabolic diseases.

 

Anti-tumour agent synthesis

(S)-(+)-Epichlorohydrin is also widely used in the synthesis of antineoplastic agents. It is used for the synthesis of (+)-cis-sylvaticin, a promising anti-tumour molecule. Through chiral modification, dextro epichlorohydrin allows the synthesis of chemical units with excellent biological activity, providing new drug candidates for tumour therapy.

 

Macquarimicins and macrolide synthesis

Dex epichlorohydrin is important in the total synthesis of Macquarimicins, a natural product with antibacterial activity. It was also used in the chemical total synthesis of the macrolide RK-397, which simplifies the synthesis of complex molecules through its unique reaction properties.

 

Enantioselective synthesis

(S)-(+)-Epichlorohydrin plays an important role in enantioselective synthesis. It is used in the synthesis of chiral structural units such as hydroxyisoxazolines, which are important in a wide range of drug discovery and the design of biologically active molecules.

 

Storage conditions: Store in sealed containers, the storage place must be locked, and the key must be given to technical experts and their assistants for safekeeping. Do not store with acids, alkalis, oxides and metal alloys, and avoid heat.

Packing: This product is packed in 25kg drums, and it can also be customized according to customers' requirements

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